Symbol
Name
ID

Ryr2
ryanodine receptor 2, cardiac
MGI:99685

Phenotype annotations related to cardiovascular system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Dilated cardiomyopathy

Sick sinus syndrome

Sudden cardiac death

Paroxysmal atrial fibrillation

Atrial standstill

Ventricular tachycardia

Bidirectional ventricular tachycardia

Effort-induced polymorphic ventricular tachycardia

Ventricular couplet

Atrioventricular block

Reduced systolic function

Syncope

Disease(s) Associated with RYR2

catecholaminergic polymorphic ventricular tachycardia 1

Mouse Phenotypes

cardiovascular system phenotype

abnormal myocardial fiber morphology

abnormal myocardial trabeculae morphology

disorganized myocardium

heart left ventricle hypertrophy

abnormal fetal cardiomyocyte morphology

abnormal fetal cardiomyocyte mitochondrial morphology

fetal cardiomyocyte vacuoles

abnormal heart morphology

thick interventricular septum

thin interventricular septum

increased heart weight

enlarged heart

cardiac hypertrophy

abnormal heart left ventricle morphology

abnormal heart right ventricle morphology

thick ventricular wall

abnormal epicardium morphology

cardiac fibrosis

abnormal cardiovascular system physiology

decreased cardiac output

abnormal cardiac muscle contractility

decreased cardiac muscle contractility

decreased ventricle muscle contractility

abnormal fetal cardiomyocyte physiology

abnormal heart echocardiography feature

abnormal sinus arrhythmia

decreased heart rate

sinus bradycardia

increased heart rate

ventricular tachycardia

absent heartbeat

irregular heartbeat

atrial fibrillation

ventricular fibrillation

ventricular premature beat

atrioventricular block

abnormal heart electrocardiography waveform feature

abnormal T wave

abnormal myocardial fiber physiology

abnormal myocardial fiber calcium currents

abnormal myocardial fiber sodium currents

abnormal response of heart to induced stress

decreased response of heart to induced stress

increased response of heart to induced stress

abnormal response to cardiac infarction

cardiomyopathy

congestive heart failure

Availability

Mouse Genotype

Ryr2^M1Btlr/Ryr2^M1Btlr

Ryr2^m2Btlr/Ryr2^m2Btlr

Ryr2^m3Btlr/Ryr2^m3Btlr

Ryr2^tm1.1Clhh/Ryr2^tm1.1Clhh

Ryr2^tm1.1Hnis/Ryr2^tm1.1Hnis

Ryr2^tm1.1Hta/Ryr2^tm1.1Hta

Ryr2^tm1.1Msnr/Ryr2^tm1.1Msnr

Ryr2^tm1.1Wex/Ryr2^tm1.1Wex

Ryr2^tm1Amks/Ryr2^tm1Amks

Ryr2^tm1Hhv/Ryr2^tm1Hhv

Ryr2^tm2.1Msnr/Ryr2^tm2.1Msnr

Ryr2^tm2.1Wex/Ryr2^tm2.1Wex

Ryr2^em1Swch/Ryr2⁺

Ryr2^tm1.1Clhh/Ryr2⁺

Ryr2^tm1.1Maya/Ryr2⁺

Ryr2^tm1.1Msnr/Ryr2⁺

Ryr2^tm1.1Swch/Ryr2⁺

Ryr2^tm1.1Swch/Ryr2^tm2.1Swch

Ryr2^tm1Sgp/Ryr2⁺

Ryr2^tm1Slh/Ryr2⁺

Ryr2^tm2.1Maya/Ryr2⁺

Ryr2^tm2.1Swch/Ryr2⁺

Ryr2^tm2Amks/Ryr2⁺

Ryr2^tm2Hhv/Ryr2⁺

Ryr2^tm3.1Amks/Ryr2⁺

Ryr2^tm3.1Hhv/Ryr2⁺

Ryr2^tm3.1Swch/Ryr2⁺

Ryr2^tm4.1Amks/Ryr2⁺

Ryr2^tm1Krbr/Ryr2^tm1Krbr
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺ (conditional)

Ryr2^tm1Krbr/Ryr2^tm3.1Swch
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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